Tubular glomerulus unbalance in children and adolescents with a history of low birth weight
Abstract
Introduction: The tubular glomerulus unbalance with tubular preponderance may contribute to the hypertension onset. This hypertensor mechanism is proposed starting from obtaining a hypertension experimental model, achieves with the administration of inhibitors of the renin-angiotensin system. It has not been studied if this same mechanism contributes to the development of hypertension that appears in individual’s adulthood with anamnesis of low birth weight due to an intrauterine growth retardation.Objective: To evaluate the existence of tubular glomerulus unbalance with tubular preponderance in normotensive individuals with a medical record of low birth weight due to an intrauterine growth retardation.
Material and Methods: 78 normotensive children and teenagers were studied. Of these, 19 were between 4 and 5 years (N-IUGR) and 20 from 14 to 15 years (A-IUGR) with a medical history of intrauterine growth retardation, the rest constituted the respective control groups. Mean arterial tension, glomerular filtration intensity and sodium proximal tubular reabsorption was determined.
Results: Increase of mean arterial tension values in teenagers with medical records of Retarded Intrauterine Growth (A-CIUR x = 86.3 ± 8.6 vs. A-Control x = 80.9 ± 4.7) were found. Glomerular Filtration Intensity and endogenous lithium clearance showed no differences. Na / Li countertransporter activity of erythrocyte decreased in both groups (N-CIUR x = 4.8 * ± 2.4 vs N-Control x = 7.9 ± 4.0) and (A-CIUR x = 1.9 * * ± 0.7 vs A-Control x = 9.6 ± 1.1).
Conclusions: There is insufficient evidence to deny or confirm the existence of tubular glomerulus unbalance with a tubular glomerulus predominance in the studied individuals.
Keywords: essential arterial hypertension, retarded intrauterine growth, tubular glomerulus unbalance, children, teenagers, glomerular filtration intensity, Sodium-lithium countertransporter activity.
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References
1. Prevalencia en Pacientes Dispensarizados por algunas Enfermedades según grupos de Edad y Sexo [en línea] Anuario Estadístico de Salud en Cuba (2000, 2001, 2003, 2004, 2005,006).Disponibleen:URL: [Consulta:11 Enero2014].
2. Alfonzo Guerra JP. Hipertensión arterial en atención primaria de salud. 1ra Ed. Científico-Técnica 2010; 1:1-8.
3. Guyton, A.C and J.E Hall. Texbook of medical physiology, 11th Ed.Elsevier Publisher Philadelphia 2006:236-248.
4. Barker DJP, Winter PD, Osmond C y cols. Weight in infancy and death from ischaemic heart disease. Lancet 1989, 2: 577-580.
5. Barber MO. Papel del desbalance glomérulo-tubular con preponderancia tubular en la patogénesis de la hipertensión arterial. [tesis doctoral]. Ciudad de La Habana: ICBP Victoria de Girón; 2007.
6. Mendoza C. Importancia ético-científica de los protocolos sobre las investigaciones en seres humanos. Med.leg.Costa Rica [revista en la Internet]. 2003 Mar [citado 2013 Mar 28]; 20(1): 37-42. Disponible en: http://www.scielo.sa.cr/scielo.php?script=sci_arttext&pid=S1409-00152003000100005&lng=es
7. Kerstin Benza and Kerstin Amann. Maternal nutrition, low nephron number and arterial hypertension in later life. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1802, Issue 12, December 2010, 1309–1317.
8. Luyckx V.A. and Brenner B.M. The Clinical Importance of Nephron Mass. J. Am. Soc. Nephrol 2010; 21(6): 898 – 910.
9. Euming Chong and Ihor V. Yosypiv. Developmental Programming of Hypertension and Kidney Disease. International Journal of Nephrology 2012; vol
10. Li Yang, Patrick K Leong, Jennifer O Chen, Nilem Patel, Sarah Ft, et al. Acute hypertension provoques internalization of proximal tubule NHE3 without inhibition of transport activity.2001(buscar).
11. Leopoldo Ardiles and Sergio Meazzano. Rol del riñón en la hipertensión sal sensible. Rev Med Chile 2010; 138: 862-867
12. Sebastiaan Wesseling, Maarten P Koeners, and Jaap A Joles. Salt sensitivity of blood pressure: developmental and sex-related effects. Am J Clin Nutr 2011; 94(2): 1928S-1932S
13. A.F. Duncan, R. J. Heyne, J. S. Morgan, N. Ahmad, and C. R. Rosenfeld. Elevated systolic blood pressure in preterm very-low-birth-weight infants ≤3 years of life. Pediatric Nephrology 2011; 26(6): 1115–1121
14. Loren P. Thompson and Yazan Al-Hasan. Impact of Oxidative Stress in Fetal Programming. Journal of Pregnancy volume 2012 (2012), Article ID 582748, 8 pages
15. J. S. Morton, C. F. Rueda-Clausen, and S. T. Davidge. Mechanisms of endothelium-dependent vasodilation in male and female, young and aged offspring born growth restricted. American Journal of Physiology 2010; 298(4):930–938
16. E. A. Herrera, A. D. Kane, J. A. Hansell, et al. A role for xanthine oxidase in the control of fetal cardiovascular function in late gestation sheep. Journal of Physiology 2012; 590(8): 1825–1837
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