The use of Reibergram in neurological manifestations of dengue

Abstract

Introduction: Neurological manifestations associated to dengue virus are being reported more frequently.

Objective:To identify the neuroimmune response evaluated by Reibergram in patients with neurological manifestations because of dengue virus.

Material and methods: The highest levels of immunoglobulin and albumin were quantified in serum and the cerebrospinal fluid in six adult patients with neurological manifestations of dengue. Q function was calculated with the concentration values in serum and cerebrospinal fluid of these analytes. Values of immunoglobulin Q vs Q albumin were introduced in the specific Reibergrams for each immunoglobulin. Albumin was used as a marker for the evaluation of blood-cerebrospinal fluid barrier.

Results:Reibergram allowed to establish the incidence of intrathecal synthesis of higher immunoglobulins (three types of patterns) in both the postinfectious and parainfectious neurological manifestations, except a patient who developed Guillain-Barre Syndrome.  It also allowed to evaluate the blood-cerebrospinal fluid barrier in each patient.

Conclusions:The use of Reibergram is important in the assessment of the immune response in patients with neurological manifestations of dengue virus.

Keywords: neurological complications, dengue, Reibergram, Guillain-Barre Syndrome, acute disseminated encephalomyelitis, encephalitis.