Reno-protective and reno-restorative effect of the Epidermal Growth Factor in the biomodel of Chronic Renal Failure

Authors

  • Carlos Rafael Núñez Cairo Universidad de Ciencias Médicas de La Habana.

Abstract

Introduction: Kidney disease is a health problem worldwide. Epidermal Growth Factor acts as cytoprotector, and trophic restorative.
Objective:  To evaluate the reno-protective and reno-restorative effect of the Epidermal Growth Factor in the biomodel of Chronic Renal Failure.
Material and Methods: 120 Wistar rats were studied in 6 groups: Negative and Positive Control, Saline Solution Single-Dose and Multiple-Dose, Epidermal Growth Factor Single-Dose and Multiple-Dose.  A single dose was applied before the damage for the reno-protective effect, and multiple doses were applied after the damage for the reno-restorative effect,at a weight ratio of 100 µg/kg.
Results: Creatinine, urea, and uric acid diminished significantly in the experimental groups, with a higher decrease for experimental group with single dose; therefore, the reno-protective effect was higher than the reno-restorative one for the treatment patterns used.
Conclusions:  Epidermal Growth Factor showed reno-protective and reno-restorative effect by diminishing the hematological variables of kidney damage. 

Keywords:  Epidermal Growth Factor, reno-protective, reno-restorative, Chronic Renal Insufficiency, 5/6 renal ablation.

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Author Biography

Carlos Rafael Núñez Cairo, Universidad de Ciencias Médicas de La Habana.

Especialista Segundo Grado en Fisiología Normal y Patológica. Profesor Asistente.

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How to Cite

1.
Núñez Cairo CR. Reno-protective and reno-restorative effect of the Epidermal Growth Factor in the biomodel of Chronic Renal Failure. Rev haban cienc méd [Internet]. 2018 May 21 [cited 2025 Jul. 1];16(7):1032-43. Available from: https://revhabanera.sld.cu/index.php/rhab/article/view/2333

Issue

Vol. 16 No. 7: Selections 2017

Section

Biomedical Basic Sciences

License

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