Tumor thromboembolism as direct cause of death

Authors

Keywords:

Thromboembolism, tumor, hepatocarcinoma.

Abstract

Introduction: Pulmonary tumor thromboembolism is the presence of accumulations of tumor cells in the pulmonary arterioles and pulmonary capillaries. Its incidence in autopsies has been described between 3% and 26% of patients with solid tumors, most frequently in breast, stomach, liver and lung tumors.

Objective:To describe clinical arguments suggesting the suspected diagnosis of tumor thromboembolism in a patient treated at the ``Dr. Carlos J. Finlay'' Hospital in Havana, Cuba.

Casepresentation: Eighty-year-old female patient with personal pathological antecedents of liver cirrhosis due to hepatitis C virus. Two months before admission she started presenting general symptoms associated with edemaof the lower limbs and diarrhea. She was admitted to an Internal Medicine service with the diagnosis of decompensated hepatic cirrhosis and the suspicion of hepatocarcinoma. On the fifth day after admission, he suddenly began with dyspnea and died.

Conclusions:Anatomopathological findings report tumor thromboembolism as a direct cause of death. Pulmonary tumor thromboembolism should be considered inthe differential diagnosis of all patients with evidence of neoplasia who are presenting dyspnea.

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References

1. Valverde Cortés JE, Morales Sánchez EI. Embolia pulmonar tumoral: una manifestación inicial infrecuente del cáncer. Revista Colombiana de Cancerología [Internet]. 2018 [Citado 20/09/2019]; 22(4):186-90. Disponible en: https://www.sciencedirect.com/science/article/abs/pii/S0123901518300581

2. Marcacuzco Quinto A,Nutu OA, San Román Manso R, Justo Alonso I, Calvo Pulido J,Manrique Municio A, et al. Complicaciones de la quimioembolización transarterial (QETA) en el tratamiento de los tumores hepáticos. Cirugía Española [Internet]. 2018 [Citado 20/09/2019];96(9):560-7. Disponible en: https://www.sciencedirect.com/science/article/abs/pii/S0009739X18301726

3. Martín Llahí M, Albillos A, Bañares R, Berzigotti A, García Criado MA, Genescà J, et al. Enfermedades vasculares del hígado. Guías Clínicas de la Sociedad Catalana de Digestología y de la Asociación Española para el Estudio del Hígado. Gastroenterología y Hepatología [Internet]. 2017 [Citado 20/09/2019];40(8):538-80. Disponible en: https://www.sciencedirect.com/science/article/pii/S0210570517301036

4. Erro Iribarren E. Vázquez Espinosa A. Roca Noval CV. Tromboembolismo pulmonar Pulmonary embolism. Medicine - Programa de Formación Médica Continuada Acreditado. Medicine [Internet]. 2018 [Citado 20/09/2019]; 12(68):3971-81. Disponible en: https://www.sciencedirect.com/science/article/pii/S0304541218302853

5. Herzog R, ‎ Rössle R. Speƶielle Pathologie des Skelets und seiner Teile. Berlín: Springer Berlin Heidelberg; 1938.

6. Canelo Aybar CG, Cuadra Urteaga JL, Fujii F, Romani Romani F, Atencia Matute FA, Verona Rubio RO. Microembolismo Tumoral y Cor-Pulmonar como manifestación de Carcinoma Hepatocelular. Rev Gastroenterol Perú [Internet]. 2008 [Citado 20/09/2019];28(1):70-3. Disponible en: http://www.scielo.org.pe/pdf/rgp/v28n1/a11v28n1

7. Hammodi A, Ali Al Azem M, Hanafy A, Nakkar T. Fatal Pulmonary Tumor Embolic Microangiopathy in Young Lady without Known Primary Malignancy. Case Reports. Critical Care [Internet]. 2014 [Citado 20/09/2019];20:[Aprox. 4 p.]. Disponible en: https://doi.org/10.1155/2014/231081

8. Morin Thibault LV, Wiseman D, Fortin M, Couture C, Provencher S. Pulmonary micro-tumor emboli resulting in paradoxical emboli: a case report. Pulm Circ [Internet].2018 [Citado 20/09/2019];8(2):[Aprox. 6 p.]. Disponible en: https://doi.org/10.1177/2045893218754853

9. Chertcoff Felipe J, Emery Nicholas C, Villagomez Renzo, Veltri Miguel A, Venditti Julio, Young Pablo, et al. Embolismo pulmonar tumoral: Reporte de dos casos. Rev méd Chile [Internet]. 2009 [Citado 20/09/2019];137(12):1613-16. Disponible en: http://dx.doi.org/10.4067/S0034-98872009001200011

10. Schriner RW, Ryu JH, Edwards WD. Microscopic pulmonary tumour embolism causing subacute cor pulmonale: a diffi cult antemortem diagnosis. Mayo Clin Proc [Internet].1991 [Citado 20/09/2019];66:143-8. Disponible en: https://www.ncbi.nlm.nih.gov/pubmed/1847222

11. Nakamura H, Adachi H, Sudoh A, Yagyu H, Kishi K, Oh Ishi S, et al. Subacute cor pulmonale due to tumor embolism. Intern Med [Internet]. 2004 [Citado 20/09/2019];43:420-3. Disponible en: https://www.ncbi.nlm.nih.gov/pubmed/15206557

12. Valverde Cortés JA, Morales Sánchez EI. Embolia pulmonar tumoral: una manifestación infrecuente del cáncer. Revista colombiana de cancerología [Internet]. 2018 [Citado 20/09/2019];22(4):186-90. Disponible en: https://www.sciencedirect.com/science/article/abs/pii/S0123901518300581

13. Lario S, Bello C, Figueredo AL, Guirola AJ. Embolismo pulmonar masivo y submasivo tratado mediante tromboaspiración (INDIGO) y fibrinólisis a bajas dosis. Experiencia de un solo centro. Revista intervencionismo [Internet]. 2017 [Citado 20/09/2019];17(4):111-9. Disponible en: http://revistaintervencionismo.com/wp-content/uploads/2017/04/2017_04_intervencionismo_original.pdf

Published

2020-09-11

How to Cite

1.
Belaunde Clausell A, Morales Días A, Rodríguez Hernández Y. Tumor thromboembolism as direct cause of death. Rev haban cienc méd [Internet]. 2020 Sep. 11 [cited 2025 Jul. 1];19(5):e3067. Available from: https://revhabanera.sld.cu/index.php/rhab/article/view/3067

Issue

Section

Clinical and pathological sciences