Fibroadenoma as the cause of tumor in the vulva. A case report
Keywords:
Vulvar fibroadenoma, vulvar mass, anogenital mammary-like glands, ectopic breast tissue.Abstract
Introduction: Fibroadenoma is a fairly common lesion in the breast tissue, but its location in the vulvar region is extremely rare, with about 60 specific cases in the literature. It is presented as a unilateral, subcutaneous and asymptomatic mass, with insidious growth. The size of this type of lesion is between 1 and 12 cm in the cases reported to date. Despite being infrequent, vulvar tumors continue to be important reasons for medical consultation. The histogenesis of this type of lesions has been the subject of discussion in recent years; two theories stand out: the presence of ectopic breast tissue, and tumor degeneration of a group of glands similar to breast tissue described as a common component of the region.
Objective: To providea polemic differencial diagnosis of vulvar tumors.
Case presentation: We present a 22-year-old patient with histopathological diagnosis of vulvar fibroadenoma. Excision of the lesion was performed, which at the macroscopic examination measured approximately 15 cm in its longitudinal axis (the largest reported in the literature).
Conclusions: Despite its low frequency of presentation, vulvar fibroadenoma needs to be considered as differencial diagnosis of vulvar tumors.
Downloads
References
1. Jiménez Tobón GA, Vélez Hoyosz A. Fibroadenoma vulvar: reporte de un caso y revisión de la literatura. Médicas UIS. 2014;27(2):93-6.
2. Friedel R. Ein Fibroadenom einer Nebenbrustdrüse im rechten Labius maius. Virchows Archiv. 1932;286(1):62-9.
3. Godoy Gijóna E, Yuste Chavesa M, Santos Brizb A, Esteban Velasco C, De Unamuno Péreza P. Mama ectópica vulvar. Actas Dermo-Sifiliográficas. 2012;103(3):229-32.
4. Baradwan S, Al Wadi K. Unilateral ectopic breast tissue on vulva in postpartum woman. Medicine. 2018;97(6):1-2.
5. Niraj M, Lisa C. Fibroadenoma of ectopic breast tissue in the vulva: a case report. J Obstet Gynecol India. 2010;60(6):529-30.
6. Galeana Castillo C, Casas Patiño D, Rodríguez Torres A, Cantú Cuevas MA. Tumores benignos de vulva: revisión y caso clínico de acrodón. Medwave [Internet]. 2014 [Citado 02/06/2019];14(1):[aprox. 2 p.]. Disponible en:https://pesquisa.bvsalud.org/portal/resource/pt/lil-716753?lang=en
7. Van der Putte SC. Anogenital "sweat" glands. Histology and pathology of a gland that may mimic mammary glands. . Am J Dermatopathol. 1991;13:557-67.
8. Van der Putte SC, Van Gorp LH. Adenocarcinoma of the mammary-like glands of the vulva: a concept unifying sweat gland carcinoma of the vulva, carcinoma of supernumerary mammary glands and extramammary Paget's disease. Journal of cutaneous pathology. 1994;21(2):157-63.
9. Burger RA, Marcuse PM. Fibroadenoma of vulva. Am J Clin Pathol. 1954;24:965-68.
10. Moreno Cid M, Moriñigo J, Alcon C, Carapeto J. Fibroadenoma de vulva. Prog Obstet Ginecol. 1999;42(2):157-59.
11. Howard BA. In the beginning: The establishment of the mammary lineage during embryogenesis. Seminars in Cell & Developmental Biology. 2012;23:574-82.
12. Macias H, Hinck L. Mammary gland development. WIREs Dev Bio. 2012;1:533-57.
13. Kazakov DV, Spagnolo DV, Kacerovska D, Michal M. Lesions of anogenital mammary-like glands: an update. Adv Anat Pathol. 2011;18(1):1-28.
14. Amalinei C, Giusca SE, Caruntu ID. Fibroadenomas of anogenital mammary-like glands: from embryogenesis anomaly to apocrine origin. Pol J Pathol. 2015;66(3):219-23.
15. Hedayat AA, Pettus JR, Marotti JD, Tafe LJ, Holubar SD, Lisovsky M. Proliferative lesion of anogenital mammary-like glands in the setting of Cowden syndrome: case report and review of the literature. Journal of cutaneous pathology. 2016;43(8):707-10.
16. Scurry J, Van der Putte SC, Pyman J, Chetty N, Szabo R. Mammary-like gland adenoma of the vulva: review of 46 cases. Pathology. 2009;41(4):372-8.
17. Peremateu MS, Absi ML, Sluga MC, Wernicke A, Marchitelli C. Bilateral Vulvar Ectopic Breast Tissue in a 38-Year-Old Woman Who is Breastfeeding: Case Report and Review of the Literature. Int J Pathol Clin Res [Internet].2018 [Citado 02/06/2019];4(2):[aprox. 2 p.]. Disponible en: https://clinmedjournals.org/articles/ijpcr/international-journal-of-pathology-and-clinical-research-ijpcr-4-071.php?jid=ijpcr
18. Kyoungchul-chul C, Myounghwan K. Ectopic breast tissue in the vagina detected at the median episiotomy site. J Med Cases. 2018;9(8):267-69.
19. Ishigaki T, Toriumi Y, Nosaka R, Kudou R. Primary ectopic breast cancer of the vulva, treated with local excision of the vulva and sentinel lymph node biopsy: a case report. Surg C Rep. 2017;3(1):69.
20. De la Vega GA, Quereshey EJ. Active ectopic breast tissue in the vulva of a postpartum patient. A case report. Rev Peru Ginecol Obst. 2020;66(1):541.
Download PDF
