COVID-19 in Pediatrics. What is known about it?

Authors

Keywords:

COVID-19, SARS-CoV-2, epidemic, child, low mortality.

Abstract

Introduction: COVID-19 is a global pandemic that threats the survival of man. This health problem shakes health services every day and generates mortality in almost all age groups.

Objective: To provide data on COVID-19 that contribute to improve quality of the care process in children with suspected SARS-CoV-2 or with the infection.

Material and Methods: A review of COVID-19 was carried out in Pubmed/Medline, Science Direct and SciELO. Google Scholar search engine was used. The words coronavirus, COVID-19, and SARS-CoV-2 in Spanish and English were used. The information obtained was classified according to the type of source. After this process, the drafting of the article began.

Development: Most pediatric cases are asymptomatic. Common clinical manifestations include fever, cough, odynophagia, and respiratory difficulty. Although asymptomatic presentation remains to be predominant, respiratory, digestive, neurological and cutaneous involvement is noted in varying degrees. Smoking and other individual conditions are related to the evolution of the disease. Laboratory tests describe leukopenia, above all, in serious ways. Elevation of procalcitonin and C-reactive protein suggest bacterial overinfection, justifying the prescription of antibiotics. Chest X-ray is usually normal, but it may reveal patchy infiltrates in patients with parenchymal involvement.  The evolution is favorable and the mortality is low.

Conclusions. COVID-19 in children has a heterogeneous presentation. It is usually asymptomatic, although it may affect systems and organs. It evolves towards recovering in 3-4 weeks.

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Author Biography

Maryla González Gorrín, Hospital Pediátrico Docente San Miguel del Padrón. La Habana. Universidad de Ciencias Médicas de La Habana. La Habana.

Especialista de Primer y Segundo Grado en Dermatología. Máster en Enfermedades Infecciosas. Profesora Auxiliar. Hospital Pediátrico Docente San Miguel del Padrón. La Habana. Cuba.

References

1.Trilla A. Un mundo, una salud: la epidemia por el nuevo coronavirus COVID-19. Med Clin (Barc) [Internet]. 2020 [Citado 08/12/2020];154(5):175-7. Disponible en: https://doi.org/10.1016/j.medcli.2020.02

2. Sánchez Duque JA, Arce Villalobos LR, Rodríguez Morales AJ. Enfermedad por coronavirus 2019 (COVID-19) en América Latina: papel de la atención primaria en la preparación y respuesta. Aten Primaria [Internet]. 2020 [Citado 08/12/2020];52(6):369-72. Disponible en: https://doi.org/10.1016/j.aprim.2020.04.001

3. Wang E, Brar K. COVID-19 in Children: An Epidemiology Study from China- ClinicalKey. Journal of Allergy and Clinical Immunology [Internet]. 2020 Jun [Citado 08/12/2020];8(6):2118-20. Disponible en: https://www.clinicalkey.es/#!/content/playContent/1-s2.0-S2213219820303755?returnurl=https:%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS2213219820303755%3Fshowall%3Dtrue&referrer=

4. Gómez Tejeda JJ, Diéguez Guach RA, Pérez Abreu MR. Alternativas terapéuticas para el manejo de la COVID-19. Rev Haban Cienc Med [Internet]. 2020 May [Citado 05/12/2020];19(Supl):e3328. Disponible en: http://www.revhabanera.sld.cu/index.php/rhab/article/view/3328

5. Organización Panamericana de la Salud. COVID-19- Respuesta de la OPS/OMS. 22 de junio del 2020. Informe nº 13 [Internet]. Washington: OPS; 2020 [Citado 08/12/2020]. Disponible en: https://www.paho.org/es/documentos/covid-19-respuesta-opsoms-reporte-13-22-junio-2020

6. Hernández Vidal O. Atentos: en cualquier lugar existe riesgo de contagio con el SARS-CoV-2 [Internet]. La Habana: Centro Nacional de Información de Ciencias Médicas; 2020 [Citado 08/12/2020]. Disponible en: https://temas.sld.cu/SARS-CoV-2/page/5/

7. Calvo C, Tagarro A, Otheo E, Epalza C. Actualización de la situación epidemiológica de la infección por SARS-CoV-2 en España. Comentarios a Las recomendaciones de manejo de la infección en pediatría. Anales Pediatria [Internet]. 2020 [Citado 08/12/2020];92(4):239-40. Disponible en: https://doi.org/10.1016/j.anpedi.2020.03.001

8. Mengana López E, Pérez Medina Y, Portuondo Kindelán D, Domínguez Redondo D, Álvarez Lambert R, Rodríguez Aguirre Y. Caracterización clínico-epidemiológica de los niños positivos a SARS-COV-2 en Santiago de Cuba. Revista Cubana de Pediatría [Internet]. 2020 Jul [Citado 05/12/2020];92(Supl):e1177. Disponible en: http://www.revpediatria.sld.cu/index.php/ped/article/view/1177

9. Alcalá Minagorre PJ, Villalobos Pinto E, Ramos Fernández JM, Rodríguez Fernández R, Vázquez Ronco M, Escosa García L, et al. Cambios a partir de la COVID-19. Una perspectiva desde la pediatría interna hospitalaria. An Pediatr (Barc) [Internet]. 2020 Nov [Citado 05/10/2020];93(5):343. Disponible en: https://www.clinicalkey.es/#!/content/journal/1-s2.0-S1695403320302071

10. González Fernández, J, Ibáñez Bernáldez M, Martínez Tejedor JA, Alama Carrizo S, Sánchez Ugena F, Montero Juanes JM. Gestión de los cadáveres durante la pandemia por COVID-19 en España. Rev Esp Med Legal [Internet]. 2020 Jul [Citado 08/12/2020];46(3):109-18. Disponible en: https://www.clinicalkey.es/#!/content/playContent/1-s2.0-S0377473220300201?returnurl=https:%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0377473220300201%3Fshowall%3Dtrue&referrer=

11. Liu W, Zhang Q, Chen J, Xiang R, Song H, Shu S, et al. Detection of COVID-19 in children in early January 2020 in Wuhan, China. N Engl J Med. 2020; 382:1370-1.

12. Ludvigsson JF. Systematic review of COVID-19 in children shows milder cases and a better prognosis than adults. Acta Pediatr. 2020; 109:1088-95.

13. Garg M, Wray CM. Hospital medicine management in the time of COVID-19: Preparing for a sprint and a marathon. J Hosp Med [Internet]. 2020 [Citado 26/06/2020];15:305-7. Disponible en: http://www.revhabanera.sld.cu/index.php/rhab/article/view/3413

14. Polo López L, Centella Hernández T, González Calle A, Bautista Hernández V, Gil Jaúrena JM, Fernández Doblas J, et al. Cirugía de cardiopatías congénitas en España durante el estado de alarma por COVID-19. Cir Cardiov. 2020; 27(4): 137-41.

15. Garg M, Reboiro ML, Sardiña González C, López Castro J. COVID 19 y Argumentum ad ignorantiam o “no todo vale”. Rev Clin Esp [Internet]. 2020 [Citado 01/10/2020];220(7):457. Disponible en: https://dx.doi.org/10.1016/j.rce.2020.04.013

16. Guanche Garcell H. COVID-19. La necesidad de nuevos paradigmas de cooperación y riesgo de los trabajadores de la salud. Rev haban cienc méd [Internet]. 2020 Jun [Citado 08/12/2020];19(Supl.):e3456. Disponible en: http://www.revhabanera.sld.cu/index.php/rhab/article/view/3456

17. Garcés Martínez M, Millán Marcelo JC. Enfrentamiento a la COVID-19: algunas precauciones esenciales para mitigar sus riesgos. Rev haban cienc méd [Internet]. 2020 Jun [Citado 08/12/2020];19(Supl.):e¬3434. Disponible en: http://www.revhabanera.sld.cu/index.php/rhab/article/view/3434

18. Díaz Colina JA. Enfrentamiento a la COVID-19. Reflexiones tras 90 días de experiencia en el Hospital Pediátrico San Miguel del Padrón. Rev haban cienc méd [Internet]. 2020 Jul [Citado 08/12/2020];19(4):e3557. Disponible en: http://www.revhabanera.sld.cu/index.php/rhab/article/view/3557

19. De Luca CD, Esposito E, Cristiani L, Mancino E, Nenna R, Cortis E, et al. Covid-19 in children: A brief overview after three months experience, Paediatric Respiratory Reviews [Internet]. 2020 [Citado 01/09/2020]35:9-14. Disponible en: https://www.clinicalkey.es/#!/content/playContent/1-s2.0-S1526054220300865?returnurl=https:%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1526054220300865%3Fshowall%3Dtrue&referrer=

20. Singhal T. A Review of Coronavirus Disease-2019 (COVID-19). Indian J Pediatr [Internet]. 2020 [Citado 13/02/2020];87:281-6. Disponible en: https://link.springer.com/article/10.1007/s12098-020-03263-6

21. Judy Y. Coronavirus – A Primer. Asia-Pacific Biotech News. Asia Pacific Biotech News [Internet]. 2020 [Citado 12/03/2020];24:[Aprox. 2 p.]. Disponible en: https://www.worldscientific.com/doi/reader/10.1142/S0219030320001172

22. Shekerdemian LS, Mahmood NR, Wolfe KK, Riggs BJ, Ross CE, Mckiernan CA, et al. Characteristics and outcomes of children with coronavirus disease 2019 (COVID-19) infection admitted to US and Canadian Pediatric Intensive Care Units. JAMA Pediatr [Internet]. 2020 [Citado 08/12/2020];174(9):868-73 Disponible en: https://jamanetwork.com/journals/jamapediatrics/article-abstract/2766037.

23. Acosta Torres J, Pérez Cutiño M, Rodríguez Prieto M, Morales González A. COVID-19 en pediatría: aspectos clínicos, epidemiológicos, inmunopatogenia, diagnóstico y tratamiento. Revista Cubana de Pediatría [Internet]. 2020 Jun [Citado 08/12/2020];92(Supl):e1152. Disponible en: http://www.revpediatria.sld.cu/index.php/ped/article/view/1152

24. Morey Olivé M, Espiau M, Mercadal Hally M, Lera Carballo E, García Patos V. Manifestaciones cutáneas en contexto del brote actual de enfermedad por coronavirus 2019. An Pediatr (Barc) [Internet]. 2020 [Citado 25/09/2020];92(6): 374-5. Disponible en: https://www.clinicalkey.es/#!/content/journal/1-s2.0-S169540332030165X

25. Plasencia Urizarri TM, Aguilera Rodríguez R, Almaguer Mederos LE. Comorbilidades y gravedad clínica de la COVID-19: revisión sistemática y meta-análisis. Rev haban cienc méd [Internet]. 2020 Jun [Citado 08/12/2020];19 (Supl.):e3389. Disponible en: http://www.revhabanera.sld.cu/index.php/rhab/article/view/3389

26. Romaní J, Baselga E, Mitjà O, Riera Martí N, Garbayo P, Vicente A, et al. Lesiones pernióticas y acrales en España durante el confinamiento por COVID: análisis retrospectivo de 12 casos. Actas Dermosifiliogr [Internet]. 2020 [Citado 01/10/2020];111(5):426-46. Disponible en: https://www.clinicalkey.es/#!/content/playContent/1-s2.0-S0001731020300879?returnurl=https:%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0001731020300879%3Fshowall%3Dtrue&referrer=

27. Lu Xiaoxia, Zhang Liqiong, Du Hui, Zhang Jingjing, Li Yuan Y, Qu Jingyu. SARS-CoV-2 Infection in Children. N Engl J Med [Internet]. 2020 [Citado 08/12/2020];382:1663-5. https://www.nejm.org/doi/full/10.1056/NEJMc2005073

28. Zhou F, Yu T, Du R, Fan G, Liu Y, Liu Z, et al. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. Lancet [Internet]. 2020 [Citado 08/12/2020];395(10229):1054-62. Disponible en: https://www.clinicalkey.es/#!/content/journal/1-s2.0-S0140673620305663

29. Gimeno Costa R, Barrios M, Heredia T, García C, de Hevia L. Insuficiencia respiratoria COVID-19: soporte con ECMO para niños y adultos jóvenes. An Pediatr (Barc) [Internet]. 2020 [Citado 19/10/2020];93(3):202-5. Disponible en: https://www.clinicalkey.es/#!/content/journal/1-s2.0-S1695403320301880

30. González Brabín A, Iglesias Bouzas MI, Nieto Moros M, Martínez de Azagra Garde A, García Salido A. Apnea neonatal como manifestación inicial de infección por SARS-CoV-2. An Pediatr (Barc) [Internet]. 2020 [Citado 19/10/2020];93(3):215-6. Disponible en: https://www.clinicalkey.es/#!/content/journal/1-s2.0-S1695403320301910

31. Qiu H, Wu J, Hong L, Luo Y, Song Q, Cheng D. Clinical and epidemiological features of 36 children with coronavirus disease 2019 (COVID-19) in Zhejiang, China: an observational cohort study- ClinicalKey. Lancet Infect Dis [Internet]. 2020 Jun [Citado 08/12/2020];20(6):689-96. Disponible en: https://www.clinicalkey.es/#!/content/journal/1-s2.0-S1473309920301985

32. Pei Y. Comparing Chinese children and adults with RT-PCR positive COVID-19: A systematic review. J Infect Public Health [Internet]. 2020 [Citado 09/10/2020];13(10):1424-31. Disponible en: https://www.clinicalkey.es/#!/content/journal/1-s2.0-S1876034120305669

33. Qifang B, Yongsheng W, Shujiang M, Chenfei Y, Xuan Z, Zhen Z, et al. Epidemiology and Transmission of COVID-19 in Shenzhen China: Analysis of 391 cases and 1,286 of their close contacts. Med Rxiv [Internet]. New York: Cold Spring Harbor; 2020 [Citado 08/12/2020]. Disponible en: https://www.medrxiv.org/search/Epidemiology%252Band%252BTransmission%252Bof%252BCOVID-19%252Bin%252BShenzhen%252BChina%253A%252BAnalysis%252Bof%252B391%252Bcases%252Band%252B1%252C286%252Bof%252Btheir%252Bclose%252Bcontacts

34. Kam K, Yung CF, Cui L, Pin RLT, Mak TM, Maiwald M, et al. A well infant with coronavirus disease 2019 (COVID-19) with high viral load. Clin Infect Dis [Internet]. 2020 [Citado 09/10/2020];71(15):[Aprox. 2 p.]. Disponible en: https://academic.oup.com/cid/article/71/15/847/5766416

35. Soetikno R, Teoh Anthony YB, Kaltenbach T, Lau J, Asokkumar R, Cabral PP, et al. Considerations in performing endoscopy during the COVID-19 pandemic. Gastrointestinal Endoscopy [Internet]. 2020 [Citado 30/04/2020];91(4):[Aprox. 2 p.]. Disponible en: https://www.giejournal.org/article/S0016-5107(20)34033-5/fulltext

36. Guan WJ, Ni ZY, Hu Y, Liang WH, Ou CQ, He JX, et al. Clinical characteristics of Coronavirus disease 2019 in China. N Engl J Med [Internet]. 2020 [Citado 05/05/2020];382:1708-20. Disponible en: https://www.nejm.org/doi/full/10.1056/NEJMoa2002032

37. Xiao F, Tang M, Zheng X, Liu Y, Li X, Shan H. Evidence for gastrointestinal infection of SARS-CoV-2. Gastroenterology [Internet]. 2020 [Citado 30/04/2020]; 158:[Aprox. 2 p.]. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7130181/

38. Góngora Gómez O, Gámez Leyva LR. Manifestaciones extrapulmonares de la infección por el nuevo Coronavirus SARS-CoV-2. Rev haban cienc méd [Internet]. 2020 [Citado 12/10/2020];19(Supl.):e3378. Disponible en: http://www.revhabanera.sld.cu/index.php/rhab/article/view/3378/2608

39. Sánchez García NL, Infante Velázquez M. Endoscopía digestiva durante la pandemia del COVID-19. Rev haban cienc méd [Internet]. 2020 [Citado 12/10/2020];19(Supl.):e3356. Disponible en: http://www.revhabanera.sld.cu/index.php/rhab/article/view/3356

40. Butowt R, Bilinska K. SARS-CoV-2: Olfaction, Brain Infection, and the Urgent Need for Clinical Samples Allowing Earlier Virus Detection. ACS Chemical Neuroscience [Internet]. 2020 [Citado 05/05/2020];11(9):1200-3. Disponible en: https://dx.doi.org/10.1021/acschemneuro.0c00172

41. Mao L, Wang M, Chen S, He Q, Chang J, Hong C, et al. Neurological manifestations of hospitalized patients with COVID-19 in Wuhan, China: a retrospective case series study. SSRN Journal [Internet]. 2020 [Citado 05/05/2020];29:[Aprox. 2 p.]. Disponible en: https://doi.org/10.1101/2020.02.22.20026500

42. Vaira LA, Salzano G, Deiana G, De Riu G. Anosmia and ageusia: common findings in COVID-19 patients. The Laryngoscope [Internet]. 2020 Abr [Citado 05/05/2020];130:[Aprox. 2 p.]. Disponible en: https://dx.doi.org/10.1002/lary.28692

43. Wan S, Xiang Y, Fang W, Zheng Y, Li B, Hu Y, et al. Clinical features and treatment of COVID-19 patients in Northeast Chongqing. J Med Virol [Internet]. 2020 [Citado 05/05/2020];92:[Aprox. 2 p.]. Disponible en: https://doi.org/10.1002/jmv.25783

44. Recalcati S. Cutaneous manifestations in COVID-19: A first perspective. J Eur Acad Dermatol Venereol [Internet]. 2020 [Citado 05/05/2020];34:[Aprox. 2p.]. Disponible en: https://www.ncbi.nlm.nih.gov/pubmed/322159

45. Mazzotta F, Troccoli T. A new vasculitis at the time of COVID-19. Eur J Pediatr Dermatol [Internet]. 2020 [Citado 08/12/2020];30(2):75-8. Disponible en: https://www.ejpd.com/journal/index.php/EJPD/article/view/2103

46. Granados Campos L, Broche del Pino L, Pérez Leal L, López Rodríguez VM. Manifestaciones cutáneas en pacientes pediátricos infectados por el coronavirus SARS-CoV-2. Rev Cub Pediatr [Internet]. 2020 [Citado 08/12/2020];92(Supl):e1171. Disponible en: http://www.revpediatria.sld.cu/index.php/ped/article/view/1171

47. Zheng F, Liao C, Fan QH, Chen HB, Zhao XG, Xie ZG, et al. Clinical characteristics of children with coronavirus disease 2019 in Hubei, China. Current Med Sc [Internet]. 2020 [Citado 08/12/2020];40(2):275-80. Disponible en: https://link.springer.com/content/pdf/10.1007/s11596-020-2172-6.pdf

48. Henry BM, Lippi G, Plebani M. Laboratory abnormalities in children with novel coronavirus disease 2019. Clin Chem Laborat Med [Internet]. 2020 [Citado 15/10/2020];58(7):1135-8 Disponible en: https://www.degruyter.com/view/journals/cclm/ahead-of-print/article-10.1515-cclm-2020-0272/article-10.1515-cclm-2020-0272.xml

49. Sinha I. Guidance for the clinical management of children admitted to hospital with suspected COVID-19. Brith Paed Resp Soc [Internet]. 2020 [Citado 20/04/2020];395:1-15. Disponible en: http://patchsa.org/wp-content/uploads/2020/03/Guidance-for-the-clinical-management-of-children-admitted-to-hospital-with-suspected-COVID-19.pdf

50. Ministerio de Salud Pública Cuba. Protocolo Nacional MINSAP vs COVID-19. Particularidades en el manejo del paciente pediátrico [Internet]. La habana: Ministerio de Salud Pública Cuba; 2020 [Citado 08/12/2020]. Disponible en: https://covid19cubadata.github.io/protocolos/protocolo-version-2.pdf

Published

2021-02-11

How to Cite

1.
Díaz Colina JA, González Gorrín M, López Hernández IC. COVID-19 in Pediatrics. What is known about it?. Rev haban cienc méd [Internet]. 2021 Feb. 11 [cited 2025 Jul. 1];20(1):e3637. Available from: https://revhabanera.sld.cu/index.php/rhab/article/view/3637

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Section

Clinical and pathological sciences