Clinical manifestations and immunological parameters post-COVID-19 in unvaccinated pediatric patients
Keywords:
COVID-19 in pediatrics, post-COVID-19 manifestations, COVID-19, immunity.Abstract
Introduction: Given the COVID-19 pandemic, consultations areestablished to monitor convalescent children and adolescents in order to
prevent, detect and treat alterations caused by the virus.
Objective: To describe the clinical manifestations and immunological
parameters in unvaccinated pediatric patients after COVID-19 disease at
the "Borras-Marfan" Pediatric Hospital from July 2021 to July 2022.
Material and Methods: A descriptive, longitudinal and prospective
investigation was carried out in 48 unvaccinated patients, aged between
0 and 18 years, of both sexes, and receiving care in a post-COVID-19
follow-up consultation. Demographic variables, blood typing, clinical
classification of the disease, Post-COVID-19 clinical manifestations, and
evaluation of immunity were studied. Descriptive statistics was used and
a multivariate analysis was performed using the statistical technique:
multiple correspondence analysis.
Results: Patients from the age group of 1 to 4 years (54.2%) and blood
type O+ (54.2%) predominated. The main clinical classification was mild
(66.7%); however, 72.9% presented post-COVID-19 clinical manifestations
and 14.3% of them maintained symptoms after 12 weeks. Blood type O+
was associated with mild disease and no post-COVID-19 manifestations.
Also, 79.9% of the patients had immune deficiency.
Conclusions: Most patients presented mild disease although they
had alterations in humoral and cellular immunity, which is why a group of
them remains under surveillance and treatment.
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