Prevention and treatment of the refractive amblyopia in pediatric keratoconus
Keywords:
Keratoconus, amblyopia, astigmatism, myopia, refractive errors, corneal topography, childrenAbstract
Introduction: The diagnosis and management of pediatrickeratoconus, establishes a challenge because of the subclinics
presentations in initial periods and the specialized ophthalmological
attention need to avoid complications as the refractive amblyopia.
Objective: Determining the visual results of the prevention and
treatment of amblyopia, in children with keratoconus attended in
Pediatrics Corneal Ectasias Provincial Consultation´s in Ciego de Avila.
Material and Methods: Pre-experimental study in 408 eyes of 224
pediatric patients with diagnosis of keratoconus, among May 2013 and
April 2023. They determined absolute and relative frequencies, measures
of dispersion and central tendency and the marginal homogeneity test
and the Wilcoxon signed-rank test, according to the variables examined.
Results: The middle ages was 10,61 years and the masculine sex
predominated. The 82,1 % presented clinical or topographic evidence
of bilateral keratoconus. Predominate the correction with spectacles or
rigid gas permeable contact lenses. The majority presented binocular
amblyopia and indication of alternating occlusive treatment's (48,5 %).
Predominated the keratoconus grade I, with evidence of keratoconic
progression as well as refractive and topographic variables. However, a
significative increase of non-amblyopic eyes was evidenced.
Conclusions: The specialized attention of pediatric keratoconus favors
the prevention and treatment of the refractive amblyopia regardless of
the keratoconic progression
Downloads
References
1. Abreu AC, Malheiro L, Coelho J, Neves MM, Gomes M, Oliveira L, et al. Implantation of intracorneal ring segments in pediatric patients: long-term follow-up. Int Med Case Rep J [Internet]. 2018 [Citado 01/06/2023];11:23-7. Disponible en: https://core.ac.uk/download/pdf/228071087.pdfhttps://core.ac.uk/download/pdf/228071087.pdf
2. Torres Netto EA, Al-Otaibi WM, Hafezi NL, Kling S, Al-Farhan HM, Randleman JB, et al. Prevalence of keratoconus in paediatric patients in Riyadh, Saudi Arabia. Br J Ophthalmol [Internet]. 2018 [Citado 11/04/2023];102(10):1436-41. Disponible en: https://web.archive.org/web/20200710090256id_/https://bjo.bmj.com/content/bjophthalmol/102/10/1436.full.pdf
3. Papageorgiou E, Asproudis I, Maconachie G, Tsironi EE, Gottlob I. The treatment of amblyopia: current practice and emerging trends. Graefes Arch Clin Exp Ophthalmol [Internet]. 2019 [Citado 12/06/2023];257(6):1061-78. Disponible en: https://www.researchgate.net/profile/Eleni-Papageorgiou/publication/330769458_The_treatment_of_amblyopia_
current_practice_and_emerging_trends/links/5c62ce3892851c48a9ce7dda/The-treatment-of-amblyopia-current-practice-and-emerging-trends.pdf
4. Duperet Carvajal D, Barrera Garcel BR, Audivert Hung Y, Duperet Carvajal Y. Rehabilitación visual en el niño ambliope. MEDISAN [Internet]. 2013 [Citado 01/07/2023];17(7):2005-11. Disponible en: https://www.redalyc.org/pdf/3684/368444994011.pdf
5. Karmacharya S, Singh P, Rizyal A, Rijal AP. Profile of amblyopia and outcome of occlusion therapy in amblyopic patients attending tertiary care hospital of Kathmandu. Nepal Med Coll J [Internet]. 2021 [Citado 07/08/2023];23(2):94-101. Disponible en: https://nmcth.edu/images/gallery/NMCJ%20Vol.%2023%20No.%202%20June%202021/94-101_
Karmacharya_S.pdf
6. Meng Z, Fu J, Chen W, Li L, Su H, Dai W, et al. Prevalence of Amblyopia and Associated Risk Factors in Tibetan Grade One Children. Ophthalmic Res [Internet]. 2021 [Citado 06/07/2023];64(2):280-9. Disponible en: https://karger.com/ore/article-pdf/64/2/280/3372253/000511264.pdf
7. Park SH. Current Management of Childhood Amblyopia. Korean J Ophthalmol [Internet]. 2019 [Citado 01/07/2023];33(6):557-68. Disponible en: https://www.ekjo.org/upload/pdf/kjo-33-557.pdf
8. Castro Cárdenas K, Puentes Expósito R, Zayas Ribalta Y, Díaz Díaz Y, Pita Alemán N, Vega Cáceres K. Características clínico-epidemiológicas del queratocono en la edad pediátrica. Mediciego [Internet]. 2018 [Citado
23/07/2023];24(2):14-23. Disponible en: https://revmediciego.sld.cu/index.php/mediciego/article/view/917/1258
9. Zhang LJ, Traish AS, Dohlman TH. Temporal keratoconus in a pediatric patient. Am J Ophthalmol Case Rep [Internet]. 2023 [Citado 16/07/2023];32:101900. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10400863/pdf/main.pdf
10. Eissa SA, Eldin NB, Nossair AA, Ewais WA. Primary outcomes of accelerated epithelium-off corneal cross-linking in progressive keratoconus in children: a 1-year prospective study. J Ophthalmol [Internet]. 2017 [Citado
19/08/2023];1923161:[Aprox. 9 p.]. Disponible en: https://downloads.hindawi.com/journals/joph/2017/1923161.pdf
11. Mahmoud S, El-Massry A, Bahgat Goweida M, Ahmed I. Pediatric keratoconus in a tertiary eye center in Alexandria: a cross-sectional study. Ophthalmic Epidemiol [Internet]. 2021 [Citado 18/07/2023];29(1):49-56.
Disponible en: https://pubmed.ncbi.nlm.nih.gov/33752567/
12. Anitha V, Vanathi M, Raghavan A, Rajaraman R, Ravindran M, Tandon R. Pediatric keratoconus. Current perspectives and clinical challenges. Indian J Ophthalmol [Internet]. 2021 [Citado 11/08/2023];69:214-25. Disponible en:
perspectives_and_clinical_challenges/links/609b6384299bf1ad8d954de7/Pediatric-keratoconus-Current-perspectives-and-clinical-challenges.pdf
13. Alió JL, Shabayek MH. Corneal higher order aberrations: a method to grade keratoconus. J Refract Surg [Internet]. 2006 [Citado 14/08/2023];22(6),539-45. Disponible en: https://pubmed.ncbi.nlm.nih.gov/16805116/
14. Méndez-Sánchez T, Sierra-Gómez C, Pons-Castro L, Hernández-Perugorría A, Castillo-Pérez A. Efectividad del tratamiento con atropina versus oclusiones en pacientes con ambliopía refractiva moderada unilateral. Rev Cubana Oftalmol [Internet]. 2023 [Citado 04/10/2023];36(2):e1758 Disponible en: https://revoftalmologia.sld.cu/index.php/oftalmologia/article/view/1758
15. Rojas Álvarez E. Queratocono en edad pediátrica: características clínico-refractivas y evolución. Centro de Especialidades Médicas Fundación Donum, Cuenca, Ecuador, 2015-2018. Rev Mex Oftalmol [Internet]. 2019 [Citado 06/06/2023];93(5):221-32. Disponible en: https://www.medigraphic.com/pdfs/revmexoft/rmo-2019/rmo195a.pdf
16. Ken-Kuo L, Yun-Wen Ch, Chun-Ting Y, Pei-Ru Li, Jiahn-Shing L, Chiun-Ho H, et al. Comparing the natural progression and clinical features of keratoconus between pediatric and adult patients. Scientific Reports [Internet]. 2022 [Citado 13/07/2023];12(1):8278. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9117301/pdf/41598_2022_Article_12070.pdf
17. Yang K, Gu Y, Xu L, Fan Q, Zhu M, Wang Q, et al. Distribution of pediatric keratoconus by different age and gender groups. Front Pediatr [Internet]. 2022 [Citado 03/07/2023];10:937246. Disponible en: https://pdfs.semanticscholar.
org/77e0/2701099c671caa3d96c4a94d121359676445.pdf
18. Gupta Y, Saxena R, Jhanji V, Maharana PK, Sinha R, Agarwal T, et al. Management Outcomes in Pediatric Keratoconus: Childhood Keratoconus Study. J Ophthalmol [Internet]. 2022 [Citado 22/08/2023];4021288:[Aprox. 8
p.]. Disponible en: https://www.researchgate.net/profile/Yogita-Gupta-2/publication/358427966_Management_Outcomes_in_Pediatric_Keratoconus_Childhood_Keratoconus_Study/links/62e228e53c0ea87887624c4e/
Management-Outcomes-in-Pediatric-Keratoconus-Childhood-Keratoconus-Study.pdf
19. Sinjab MM. Corneal Tomography in Clinical Practice (Pentacam System): Basics and Clinical Interpretation. 4 ed [Internet]. Nueva Delhi (India): JP Medical Ltd; 2021 [Citado 22/08/2023]. Disponible en: https://books.
google.es/books?hl=es&lr=&id=ccdUEAAAQBAJ&oi=fnd&pg=PP1&dq=basic+indicators+pentacam+tomography&ots=y3-dz4kPPR&sig=HEN_Ces1_595dCI56oFmN6b0vsM#v=onepage&=basic%20indicators%20pentacam%20tomography&f=false
20. Pons L, Pérez Suárez RG, Cárdenas T, Méndez Sánchez TJ, Naranjo RM. Características del astigmatismo en niños. Rev Cubana Oftalmol [Internet]. 2019 [Citado 04/12/2023];32(2):1-16. Disponible en: http://scielo.sld.cu/
scielo.php?script=sci_arttext&pid=S0864-21762019000200008&lng=es
21. Rico-Del-Viejo L, Garcia-Montero M, Hernández-Verdejo JL, García-Lázaro S, Gómez-Sanz FJ, Lorente-Velázquez A. Nonsurgical Procedures for Keratoconus Management. J Ophthalmol [Internet]. 2017 [Citado 12/08/2023];
2017:9707650. Disponible en: https://downloads.hindawi.com/journals/joph/2017/9707650.pdf
22. Lim L, Lim EWL. Current perspectives in the management of keratoconus with contact lenses. Eye [Internet]. 2020 [Citado 17/08/2023];34:2175-96. Disponible en: https://www.nature.com/articles/s41433-020-1065-z
23. Şengör T, Aydın Kurna S. Update on Contact Lens Treatment of Keratoconus. Turk J Ophthalmol [Internet]. 2020 [Citado 01/06/2023];50:234-44. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7469902/pdf/TJO-50-234.pdf
24. Taşçı YY, Saraç Ö, Çağıl N, Yeşilırmak N. Comparison of Hybrid Contact Lenses and Rigid Gas-Permeable Contact Lenses in Moderate and Advanced Keratoconus. Turk J Ophthalmol [Internet]. 2023 [Citado
10/06/2023];53:142-8. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10286838/pdf/TJO-53-142.pdf
25. Hernández-Santos L, Cárdenas-Díaz T, Méndez--Sánchez T, Hernández-Perugorria A, Palacios-Sánchez M. Caracterización de la ambliopía refractiva. Rev Cubana Oftalmol [Internet]. 2022 [Citado 4 Nov 2023];35(1):e1195.
Disponible en: https://revoftalmologia.sld.cu/index.php/oftalmologia/article/view/1195
26. Jarwal PN, Singh R. Evaluation of Amblyopia in School Going Children. Delhi J Ophthalmol [Internet]. 2020 [Citado 22/06/2023];30(3):46-50. Disponible en: https://journals.lww.com/djo/abstract/2020/30030/evaluation_of_amblyopia_in_school_going_children.11.aspx