Efficacy of the use of nanoparticles in the administration of drugs against lung cancer
Keywords:
Nanoparticles, drug administration, Medical Oncology, lung cancerAbstract
Introduction: Nanoparticles offer several advantages including specifically targeted drug delivery to improve stability and eradication of toxicity; active and passive drug targeting can be achieved by size reduction, controlled release drug delivery, and a best diagnostic imaging tool for earlier detection of cancer cells.
Objective: To provide researchers with an overview of the current research and technological development of the use of nanoparticles for lung cancer therapy.
Material and Methods: A bibliographic revision study was performed using a methodological design that included the search, selection, synthesis and analysis of articles on the effectiveness of the use of nanoparticles in the administration of drugs against lung cancer. A protocol was developed with methodological guidelines and a bibliographic record for the registration and content analysis of each article. The protocol and the sheet were submitted to validation by five experts selected for their expertise and training in research in Biochemistry, Biotechnology, Biomedicine, Oncology and Pneumopathology.
Results: The growing importance of nanotechnology in the field of biomedical applications has encouraged the development of new nanomaterials with multiple functions. There is a set of notable features of nanoparticle-based detection systems that support their usefulness in the treatment of lung cancer.
Conclusions: Despite the advantages, many challenges remain unresolved, including scale-up issues, economical production, drug pharmacokinetics, and image construction. Issues with nanotoxicity and regulatory guidelines and obstacles need to be resolved.
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