Quality of life in Alzheimer's patients and their caregivers according to the SF-36 questionnaire. A systematic review
Keywords:
Quality of life, Alzheimer's disease, SF-36, caregivers, intervention strategies.Abstract
Introduction: Alzheimer's disease progressively impairs patients' autonomy and requires ongoing care, usually assumed by family members. This situation creates a significant emotional and physical burden for both patients and their caregivers.
Objective: To evaluate the quality of life of patients with Alzheimer's disease and their caregivers by applying the SF-36 questionnaire.
Material and Methods: A systematic review was conducted in the SCOPUS database using the PRISMA methodology, with a closing date of October 14, 2024. A total of 195 initial studies were filtered down to 20 primary studies. All studies related to the quality of life of patients and caregivers were included using the SF-36; those that did not answer the research question, had an errata report or retraction letter, and those with conflicts of interest were excluded.
Results: The results show that the quality of life of Alzheimer's patients is particularly low in terms of mental health, reflecting a considerable impact on their mood and ability to maintain relationships. For caregivers, physical health is perceived as moderate, with an average of 62.97, while mental health is more vulnerable, with an average of 57.54 attributed to constant emotional pressure and stress from prolonged caregiving.
Conclusions: Patients with Alzheimer's disease have a better perception of their physical health than their mental health. Caring for patients with Alzheimer's disease significantly affects caregivers' quality of life, especially in the emotional realm. The most effective interventions combine psychoeducational support and respite strategies, improving both caregivers' mental and physical health.Downloads
References
1. Llibre-Rodriguez JJ, Gutiérrez Herrera R, Guerra Hernández MA. Enfermedad de Alzheimer: actualización en su prevención, diagnóstico y tratamiento. Rev haban cienc méd [Internet]. 2022 [Citado 03/04/2024]; 21(3). Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S1729-519X2022000300004&lng=es
2. Self, WK., Holtzman, DM. Emerging diagnostics and therapeutics for Alzheimer disease. Nat Med [Internet]. 2023 [Citado 03/04/2024]; 29(9): 2187–99. Disponible en: https://doi.org/10.1038/s41591-023-02505-2
3. Xing B, Li H, Hua H, Jiang R. Economic burden and quality of life of patients with dementia in China: a systematic review and meta-analysis. BMC Geriatr [Internet]. 2024 [Citado 03/04/2024]; 24(1): 789. Disponible en: https://doi.org/10.1186/s12877-024-05359-6
4. Landeiro F, Mughal S, Walsh K, Nye E, Morton J, Williams H, et al. Health-related quality of life in people with predementia Alzheimer’s disease, mild cognitive impairment or dementia measured with preference-based instruments: a systematic literature review. Alzheimer's research & therapy [Internet]. 2020 [Citado 03/04/2024];12:1-14. Disponible en: https://doi.org/10.1186/s13195-020-00723-1
5. Pastuña Doicela RH. Calidad de vida de los cuidadores de personas con enfermedad de Alzheimer: Revisión integrativa. Enferm investig [Internet]. 2021 [Citado 03/04/2024]; 6(5):37–45. Disponible en: https://revistas.uta.edu.ec/erevista/index.php/enfi/article/view/1454
6. Ruidiaz-Gómez KS, Cacante-Caballero JV. Desarrollo histórico del concepto, Calidad de Vida: una revisión de la literatura. Rev cienc. cuidad [Internet]. 2021 [Citado 03/04/2024];18(3):86-99. Disponible en: https://revistas.ufps.edu.co/index.php/cienciaycuidado/article/view/2539
7. Ding X, Abner E, Schmitt F, Crowley J, Goodman P, Kryscio R. Mental Component Score (MCS) from health-related quality of life predicts incidence of dementia in US males. The journal of prevention of Alzheimer's disease [Internet]. 2021; 8: 169-74. Disponible en: https://doi.org/10.14283/jpad.2020.50
8. Parkman S, Olausson J. Efficacy of yoga for caregivers of persons with dementia: An integrative review. Nordic College of Caring Science [Internet]. 2023 [Citado 03/04/2024]; 37: 980990. Disponible en: https://pubmed.ncbi.nlm.nih.gov/37070342/
9. Santiago Ramírez J, Lombas Fouletier AS.I ntervenciones que mejoran la calidad de vida en cuidadores informales de personas con Alzheimer u otras demencias: una revisión sistemática [Tesis de Maestría]. España:Zaguan; 2024 [Citado 03/04/2024]. Disponible en: https://zaguan.unizar.es/record/145860/files/TAZ-TFM-2024-858.pdf
10. Ko E, Wongvibul T, Rose K M, Jun J. The effects of self-guided interventions on stress, burden, and mental health in caregivers of people living with dementia: A systematic review. International Journal of Nursing Studies Advances [Internet]. 2023 [Citado 03/04/2024];5:1-23. Disponible en: https://www.sciencedirect.com/science/article/pii/S2666142X23000255
11. Letrondo PA, Ashley SA, Flinn A, Burton A, Kador T, Mukadam N. Systematic review of arts and culture-based interventions for people living with dementia and their caregivers. Ageing Research Reviews. 2023; 83:1-9.
12. Sánchez-Rodríguez J, Torrellas-Morales C, Fernández-Gómez M, Martín-Vallejo J. Influencia de la reserva cognitiva en la calidad de vida en sujetos con enfermedad de Alzheimer. Anales de psicología [Internet]. 2013;29(3):762-71. Disponible en: http://dx.doi.org/10.6018/analesps.29.3.138201
13. Novella J, Boyer F, Jochum C, Jovenin N, Morrone I, Jolly D, et al. Health status in patients with Alzheimer’s disease: an investigation of inter-rater agreement. Quality of Life Research. 2006; 15:811-9.
14. Novella J, Jochum C, Ankri J, Morrone I, Jolly D, Blanchard F. Measuring general health status in dementia: practical and methodological issues in using the SF-36. Aging Clinical and Experimental Research [Internet]. 2001[Citado 03/04/2024];13: 362-9. Disponible en: https://link.springer.com/article/10.1007/BF03351504
15. Weiss E, Papousek I, Fink A, Matt T, Marksteiner J, Deisenhammer E. Lebensqualität bei älteren Personen mit unterschiedlichem Schweregrad von kognitiver Beeinträchtigung. neuropsychiatrie [Internet]. 2012 [Citado 03/04/2024]; 2(26):72-7. Disponible en: https://www.infona.pl/resource/bwmeta1.element.springer-00b69331-b496-316c-aa0b-c34a0a6f71db
16. Uyar F, Özmen D, Mavioğlu H, Atalay N. Assessment of the impact of dementia care and support program in both patient and caregiver outcomes: an intervention study. Turkish Journal of Geriatrics/Türk Geriatri Dergisi [Internet]. 2019 [Citado 03/04/2024], 22(4). Disponible en: https://openurl.ebsco.com/EPDB%3Agcd%3A11%3A3994491/detailv2?sid=ebsco%3Aplink%3Ascholar&id=ebsco%3Agcd%3A141468113&crl=c
17. Kurz X, Scuvée-Moreau J, Vernooij-Dassen M, Dresse A. Cognitive impairment, dementia and quality of life. Acta Neurologica Belgica [Internet]. 2003 [Citado 03/04/2024]; 103. Disponible en: https://orbi.uliege.be/bitstream/2268/34839/1/KurzActaNeurolBelg02-.pdf
18. Papageorgiou N, Zygogianni A, Parpa E, Tsilika E, Mystakidou K. Comparative Analysis of Quality of Life and Attachment Style among Cancer and Dementia Informal Caregivers. Advances in Gerontology [Internet]. 2022 [Citado 03/04/2024]; 12(2):194-9. Disponible en: https://link.springer.com/article/10.1134/S2079057022020151
19. Martín‐Carrasco M, Franco M, Pelegrín C, Roy P, Iglesias C, Ros S. Effectiveness of a psychoeducational intervention program in the reduction of caregiver burden in Alzheimer's disease patients' caregivers. International Journal of Geriatric Psychiatry: A journal of the psychiatry of late life and allied sciences [Internet]. 2009; 24(5): 489-99. Disponible en: https://doi.org/10.1002/gps.2142
20. Prieto-Prieto J, Madruga M, Adsuar J, González-Guerrero J, Gusi N. Effects of a home-based exercise program on health-related quality of life and physical fitness in dementia caregivers: a randomized controlled trial. International journal of environmental research and public health [Internet]. 2022; 19(15): 9319. Disponible en: https://doi.org/10.3390/ijerph19159319
21. Alonso-Babarro A, Garrido-Barral A, Matín-Martínez, Francisco-Morejón N. Evaluación de una intervención en cuidadores de pacientes con demencia (programa ALOIS) mediante una escala de calidad de vida. Revista española de Geriatría y Gerontología [Internet]. 2005; 40:40-5. Disponible en: https://doi.org/10.1016/S0211-139X(05)75072-1
22. Gusi N, Prieto J, Madruga M, Garcia JM, González-Guerrero JL. Health-related quality of life and fitness of the caregiver of patient with dementia. Medicine and science in sports and exercise [Internet]. 2009; 41(6): 1182-7. Disponible en: https://doi.org/10.1249/mss.0b013e3181951314
23. Arango-Lasprilla J, Lehan T, Drew A, Moreno A, Deng X, Lemos M. Health-related quality of life in caregivers of individuals with dementia from Colombia. American Journal of Alzheimer's Disease & Other Dementias® [Internet]. 2010; 25(7): 556-61. Disponible en: https://doi.org/10.1177/1533317510382287
24. Garzón-Maldonado F, Gutiérrez-Bedmar M, García-Casares N, Pérez-Errázquin F, Gallardo-Tur A, Martínez-Valle M. Health-related quality of life in caregivers of patients with Alzheimer disease. Neurología (English Edition) [Internet]. 2017; 32(8): 508-15. Disponible en: https://doi.org/10.1016/j.nrleng.2016.02.011
25. Argimon J, Limon E, Vila J, Cabezas C. Health-related quality of life in carers of patients with dementia. Family practice [Internet]. 2004; 21(4): 454-7. Disponible en: https://doi.org/10.1093/fampra/cmh418
26. Fowler C, Kim MT. Home visits by care providers–Influences on health outcomes for caregivers of homebound older adults with dementia. Geriatric Nursing [Internet]. 2015;36(1): 25-9. Disponible en: https://doi.org/10.1016/j.gerinurse.2014.09.002
27. Lucijanić J, Baždarić K, Lucijanić M, Maleković H, Hanževački M, Jureša V. Predictors of health-related quality of life in informal caregivers of dementia patients in Zagreb, Croatia, a cross sectional study. Psychiatria Danubina [Internet]. 2021 [Citado 03/04/2024];33(suppl 13):189-98. Disponible en: https://hrcak.srce.hr/file/395225
28. Molinuevo JL, Hernández B. Perfil del cuidador informal asociado al manejo clínico del paciente con enfermedad de Alzheimer no respondedor al tratamiento sintomático de la enfermedad. Neurología [Internet]. 2011; 26(9): 518-27. Disponible en: https://doi.org/10.1016/j.nrl.2011.05.011
29. Pinto M, Barbosa D, de Lucena C, Ferreira L, Souza D, Silva A. Quality of life among caregivers of elders with Alzheimer's disease. Acta Paulista de Enfermagem [Internet]. 2009; 22: 65257. Disponible en: https://doi.org/10.1590/S0103-21002009000500009
30. Cerquera A, Tiga D, Álvarez W, Dugarte E, Plata L, Jaimes L. Calidad de vida en cuidadores informales de pacientes con Alzheimer tras implementación de programa multicomponente. Horizonte de Enfermería [Internet]. 2021 [Citado 03/04/2024]; 32(3):266-82. Disponible en: https://horizonteenfermeria.uc.cl/index.php/RHE/article/view/44255
31. Lai C, Cipriani M, Renzi A, Luciani M, Lombardo L, Aceto P. The effects of the perception of being recognized by patients with alzheimer disease on a caregiver’s burden and psychophysical health. American Journal of Hospice and Palliative Medicine®[Internet]. 2018; 35(9): 1188-94. Disponible en: https://doi.org/10.1177/1049909118766316
32. Perales J, Cosco T, Stephan F, Haro J, Brayne C. Health-related quality-of-life instruments for Alzheimer's disease and mixed dementia. International Psychogeriatrics [Internet]. 2013; 25(5): 691-706. Disponible en: https://doi.org/10.1017/s1041610212002293
33. Hazzan A, Ploeg J, Shannon H, Raina P, Oremus M. Association between caregiver quality of life and the care provided to persons with Alzheimer’s disease: protocol for a systematic review. Systematic Reviews [Internet]. 2013 [Citado 03/04/2024]; 2:1-5. Disponible en: https://link.springer.com/article/10.1186/2046-4053-2-17?utm_source=getftr&utm_medium=getftr&utm_campaign=getftr_pilot
Download PDF
