Human papilloma virus related to head and neck cancer. A case presentation
Keywords:
Neoplasia, cirugía, histopatología, papillomaviridae, conducta sexual.Abstract
Introduction: Head and neck cancer currently has the sixth highest incidence worldwide. The Human Papilloma Virus (HPV) is a small deoxyribonucleic acid (DNA) virus with more than 200 subtypes. Remarkable features have been reported in head and neck cancer according to HPV status. Histopathologically, cancer with positive HPV tends to be a poorly differentiated basaloid and keratinized histologic type tumor.
Objective: To present the relationship between HPV- associated head and neck cancer (subtypes 16 and 18) in a young patient, describing the surgical approach performed; to show the results of the clinical practice taking into account the staging, the depth of the invasion, and the treatment received; and to assess the oncological outcome and the patient's satisfaction with esthetic and function.
Case Presentation: A 40-year-old male patient is presented. He reports no history of smoking, but occasional alcohol intake, and the practice of oro-genital sexual habits in bisexual relationships. He also has a family history of cancer. The patient presents a localized ulceration in the lateral border of the tongue. The histopathological diagnosis indicated infiltrating large keratinizing squamous cell carcinoma.
Conclusions: Associated risk factors such as smoking and alcohol consumption are decisive on the outcome of this type of cancer, so the diagnosis and progression of the disease in this group of positive HPV subjects requires a different approach from the commonly implemented one.
Keywords: Neoplasia, surgery, histopathology, papillomaviridae, sexual behavior.Downloads
References
1. Pytynia KB, Dahlstrom KR, Sturgis EM. Epidemiology of HPV-associated oropharyngeal cancer. Oral Oncol [Internet]. 2014 [cited: 11/03/2019]; 50(5):380-386. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4444216/
2. Mallen-St Clair J, Alani M, Wang M. Srivatsan E S. Human papillomavirus in oropharyngeal cancer: The changing face of a disease. Biochimica et Biophysica Acta (BBA)-Reviews on Cancer, 2016; 1866(2):141-150.
3. Jamieson L, Garvey G, Hedges J, Mitchell A, Dunbar T, Leane C, Roder D. Human Papillomavirus and Oropharyngeal Cancer Among Indigenous Australians: Protocol for a Prevalence Study of Oral-Related Human Papillomavirus and Cost-Effectiveness of Prevention. JMIR research protocols. 2018; 7(6): e10503.
4. Wagner S, Sharma SJ, Wuerdemann N, Knuth J, Reder H, Wittekindt C, Klussmann J, P: Human Papillomavirus-Related Head and Neck Cancer. Oncol Res Treat [Internet]. 2017 [cited: 11/03/2019];40:334-340. Available from: https://www.karger.com/Article/Pdf/477252
5. Young D, Xiao C C , Murphy B, Moore M, Fakhry C, Day T A. Increase in head and neck cancer in younger patients due to human papillomavirus (HPV). Oral oncology [Internet]. 2015 [cited: 11/03/2019]; 51(8):727-730. Available from: https://www.sciencedirect.com/science/article/abs/pii/S1368837515001827?via%3Dihub
6. Derek B, Maleki Z. HPV-related head and neck squamous cell carcinoma: An update and review. Journal of the American Society of Cytopathology [Internet]. 2016 [cited: 11/03/2019]; 5(4):203-215. Available from: https://www.sciencedirect.com/science/article/pii/S221329451530003X
7. Nulton T J, Kim N K, DiNardo L J, Morgan IM, Windle B. Patients with integrated HPV16 in head and neck cancer show poor survival. Oral oncology [Internet]. 2018 [cited: 11/03/2019]; 80:52-55. Available from: https://www.sciencedirect.com/science/article/pii/S1368837518301179
8. Mydlarz W K, Chan JY, Richmon J D. The role of surgery for HPV-associated head and neck cancer. Oral oncology [Internet]. 2015 [cited: 11/03/2019]; 51(4):305-313. Available from: https://www.sciencedirect.com/science/article/abs/pii/S1368837514003005
9. Ellis M. A, Graboyes E M, Wahlquist A. E, Neskey D. M, Kaczmar J. M, Schopper H. K, Day T. A. Primary surgery vs radiotherapy for early stage oral cavity cancer. Otolaryngology–Head and Neck Surgery [Internet]. 2018 [cited: 11/03/2019]; 158(4):649-659. Available from: https://journals.sagepub.com/doi/abs/10.1177/0194599817746909#articleCitationDownloadContainer
10. Walvik L, Svensson A. B, Friborg J, Lajer C B. The association between human papillomavirus and oropharyngeal squamous cell Carcinoma: Reviewed according to the Bradford Hill criteria for causality. Oral oncology [Internet]. 2016 [cited: 11/03/2019]; 63:61-65. Available from: https://www.sciencedirect.com/science/article/abs/pii/S1368837516302111
11. Rettig E M, Zaidi M, Faraji F, Eisele D. W, El Asmar M, Fung N, Fakhry C. Oropharyngeal cancer is no longer a disease of younger patients and the prognostic advantage of Human Papillomavirus is attenuated among older patients: Analysis of the National Cancer Database. Oral oncology [Internet]. 2018 [cited: 11/03/2019]; 83:147-153. Available from: https://www.sciencedirect.com/science/article/abs/pii/S136883751830232X
12. Bansal A, Singh M. P, Rai B. Human papillomavirus-associated cancers: A growing global problem. International Journal of Applied and Basic Medical Research [Internet]. 2016 [cited: 11/03/2019]; 6(2):84-89. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4830161/
Download PDF
