Hybrid immunity of the SARS-CoV-2 vaccine after the third doses in health workers
Keywords:
Hybrid immunity, SARS-CoV-2, COVID-19, neutralizing antibodies, vaccine, BNT162b2, BBIBP-CorV, healthcare workersAbstract
Introduction: Hybrid immunity is the immune response of peopleinfected with COVID-19 who received the SARS-CoV-2 vaccine. This
combination is more powerful than the immunity that is generated
after vaccination or infection alone. Objective: To compare the hybrid
immunity of the SARS-CoV-2 vaccine after the third doses in healthcare
workers from a public hospital in Peru.
Objective: To compare the hybrid immunity of the SARS-CoV-2
vaccine after the third doses in healthcare workers from a public hospital
in Peru.
Material and Methods: A prospective observational cohort study
was conducted on health workers at the Carrion Hospital in Huancayo-
Peru; a total of 174 participants completed the study. Quantitative
monitoring of neutralizing antibodies (NAb) and immunoglobulin G (IgG)
was achieved after the first, second, and third doses of vaccination and
compared with the time of COVID-19 infection.
Results: The average age was 39 years. The average NAb was 3736
U in participants who became infected with COVID-19 after the second
vaccine, and with the third dose it was 3039 U. In the group not infected
with COVID-19, the average NAb production after the second dose was
1102U (p=0.009), and with the third vaccine, it was 2782U (p=0.685).
Conclusions: Hybrid immunity is significantly high after the second
dose, with a non-significant increase after the third dose of the vaccine
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