Nanoparticles in dentistry: a systematic review

Authors

Keywords:

Nanoparticles, Dentistry, Nanoparticle synthesis, Dental diseases.

Abstract

Introduction: Dentistry has been transformed by nanotechnology in recent decades, offering significant advances in diagnosis and treatment. Knowledge gaps persist in Latin America regarding the use of nanoparticles in dental biomaterials, justifying a systematic review.

Objective: To analyze the use of nanoparticles in dentistry, investigating the most commonly used material, synthesis methods, treated dental conditions, bacteria targeted, and specific applications.

Materials and Methods: A systematic review was conducted following the PRISMA 2020 methodology, evaluating eligibility criteria in 232 studies obtained from Scopus. Data were categorized, bias risks assessed, and synthesized to address research questions.

Results: Out of 112 identified studies, materials such as silver and zinc oxide were highlighted, with varied synthesis methods. Nanoparticles showed efficacy in treating caries and periodontal diseases, targeting bacteria such as Streptococcus mutans and Staphylococcus aureus.

Conclusions: The integration of nanoparticles in dentistry has shown promise in improving the prevention and treatment of dental diseases. Further research is needed to address limitations and optimize their clinical application.

Downloads

Download data is not yet available.

References

1. Jandt KD, Watts DC. Nanotechnology in dentistry: present and future perspectives on dental nanomaterials. Dent Mater [Internet]. 2020 [Citado 13/05/2024];36(11):1365-78. Disponible en: https://doi.org/10.1016/j.dental.2020.08.006

2. Barot T, Rawtani D, Kulkarni P. Nanotechnology-based materials as emerging trends for dental applications. Rev Adv Mater Sci [Internet]. 2021 [Citado 13/05/2024];60(1):173-89. Disponible en: https://doi.org/10.1515/rams-2020-0052

3. Dakhale R, Paul P, Achanta A, Ahuja KP, Meshram M. Nanotechnology innovations transforming oral health care and dentistry: a review. Cureus [Internet]. 2023 [Citado 13/05/2024];15(10):e46423. Disponible en: https://doi.org/10.7759/cureus.46423

4. Nambiar P, Madhu PP, Reche A, Moharil S. Nanoparticles in Dentistry ; a review. International Arab Journal of Dentistry [Internet]. 2023 [Citado 13/05/2024];14(2). Disponible en: https://digitalcommons.aaru.edu.jo/iajd/vol14/iss2/19

5. Díaz Castro L. Aplicaciones contemporáneas de nanomateriales en ciencias odontológicas [Tesis de Especialidad]. México: Universidad Autonoma del Estado de México; 2023 [Citado 10/05/2024]. Disponible en: http://ri.uaemex.mx/handle/20.500.11799/139083

6. Aati S, Chauhan A, Shrestha B, Rajan SM, Aati H, Fawzy A. Development of 3D printed dental resin nanocomposite with graphene nanoplatelets enhanced mechanical properties and induced drug-free antimicrobial activity. Dent Mater [Internet]. 2022 [Citado 13/05/2024]; 38(12):1921-33. Disponible en: https://doi.org/10.1016/j.dental.2022.10.001

7. Reddy JR, Kannan KP, Sankaran K, Rengasamy G, Priya VV, Sathishkumar P. Eradication of dental pathogens using flavonoid rutin mediated silver-selenium nanoparticles. Inorg Chem Commun [Internet]. 2023 [Citado 13/05/2024];157:111391. Disponible en: https://doi.org/10.1016/j.inoche.2023.111391

8. Hamad AM, Mahmood Atiyea Q. In vitro study of the effect of zinc oxide nanoparticles on Streptococcus mutans isolated from human dental caries. J Phys [Internet]. 1 de mayo de 2021 [Citado 13/05/2024];1879(2):022041. Disponible en: https://doi.org/10.1088/1742-6596/1879/2/022041

9. Bai X, Lin C, Wang Y, Ma J, Wang X, Yao X, Tang B. Preparation of Zn doped mesoporous silica nanoparticles (Zn-MSNs) for the improvement of mechanical and antibacterial properties of dental resin composites. Dent Mater [Internet]. 2020 [Citado 13/05/2024];36(6):794-807. Disponible en: https://doi.org/10.1016/j.dental.2020.03.026

10. Yepes-Nuñez JJ, Urrútia G, Romero-García M, Alonso-Fernández S. Declaración PRISMA 2020: una guía actualizada para la publicación de revisiones sistemáticas. Rev Espanola Cardiol [Internet]. 2021 [Citado 13/05/2024];74(9):790-9. Disponible en: https://doi.org/10.1016/j.recesp.2021.06.016

11. Dadkan S, Khakbiz M, Ghazanfari L, Chen M, Lee KB. Evaluation of antibacterial and mechanical features of dental adhesives containing colloidal gold nanoparticles. J Mol Liq [Internet]. 2022 [Citado 13/05/2024]:119824. Disponible en: https://doi.org/10.1016/j.molliq.2022.119824

12. Devilakshmi M, Ramasubburayan R. Green synthesis of TiO2 nanoparticles using Terminalia chebula and its potent antibiofilm activity against dental caries-associated bacterium Streptococcus mutans. Biocatal Agric Biotechnol [Internet]. 2023 [Citado 13/05/2024];54:102953. Disponible en: https://doi.org/10.1016/j.bcab.2023.102953

13. Zhao Y, Xu J, Wang Q, Xie ZH, Munroe P. (TiZrNbTaMo) N nanocomposite coatings embedded with silver nanoparticles: imparting mechanical, osteogenic and antibacterial traits to dental implants. J Alloy Compd [Internet]. 2023 [Citado 13/05/2024]:172824. Disponible en: https://doi.org/10.1016/j.jallcom.2023.172824

14. Fernández-Arias M, Boutinguiza M, Del Val J, Covarrubias C, Bastias F, Gómez L, et al. Copper nanoparticles obtained by laser ablation in liquids as bactericidal agent for dental applications. Appl Surf Sci [Internet]. 2020 [Citado 13/05/2024];507:145032. Disponible en: https://doi.org/10.1016/j.apsusc.2019.145032

15. Wang Y, Ding Y, Deng J, Nie R, Meng X. Antibacterial one-step self-etching dental adhesive with silver nanoparticles synthesized in situ. J Dent [Internet]. 2023 [Citado 13/05/2024];129:104411. Disponible en: https://doi.org/10.1016/j.jdent.2023.104411

16. Ortiz-Magdaleno M, Sánchez-Vargas L, Gardea-Contreras D, Campos-Ibarra V, Pozos-Guillén A, Márquez-Preciado R. Antibiofilm properties of silver nanoparticles incorporated into polymethyl methacrylate used for dental applications. Bio Med Mater Eng [Internet]. 2023 [Citado 13/05/2024]:1-17. Disponible en: https://doi.org/10.3233/bme-222513

17. Takamiya AS, Monteiro DR, Gorup LF, Silva EA, de Camargo ER, Gomes-Filho JE, et al. Biocompatible silver nanoparticles incorporated in acrylic resin for dental application inhibit Candida albicans biofilm. Mater Sci Eng [Internet]. 2021 [Citado 13/05/2024];118:111341. Disponible en: https://doi.org/10.1016/j.msec.2020.111341

18. Alcudia A, Begines B, Rodriguez-Lejarraga P, Greyer V, Godinho VC, Pajuelo E, et al. Development of porous silver nanoparticle/polycaprolactone/polyvinyl alcohol coatings for prophylaxis in titanium interconnected samples for dental implants. Colloid Interface Sci Commun [Internet]. 2022 [Citado 13/05/2024];48:100621. Disponible en: https://doi.org/10.1016/j.colcom.2022.100621

19. Ramyaa SK, Subitha P, Srinivasan N, Ramachandran M, Shoba N. Fabrication of dexamethasone-silver nanoparticles entrapped dendrimer collagen matrix nanoparticles for dental applications. Biointerface Res Appl Chem [Internet]. 2021 [Citado 13/05/2024];11(6):14935-55. Disponible en: https://doi.org/10.33263/briac116.1493514955

20. Senthil R, Çakır S. Nano apatite growth on demineralized bone matrix capped with curcumin and silver nanoparticles: dental implant mechanical stability and optimal cell growth analysis. J Oral Biosci [Internet]. 2023 [Citado 13/05/2024]; ;66(1):232-40. Disponible en: https://doi.org/10.1016/j.job.2023.12.004

21. Khan AS, Alhamdan Y, Alibrahim H, Almulhim KS, Nawaz M, Ahmed SZ, et al. Analyses of experimental dental adhesives based on zirconia/silver phosphate nanoparticles. Polymers [Internet]. 2023 [Citado 13/05/2024];15(12):2614. Disponible en: https://doi.org/10.3390/polym15122614

22. Gaikwad S, Torane R, Parthibavarman M. Cassia fistula–assisted green synthesis, characterization and their antimicrobial activity of zinc oxide zno nanomaterial’s an intracanal microbial agent on oral dental caries. Nanotechnol Russ [Internet]. 2020 [Citado 13/05/2024];15(11-12):760-9. Disponible en: https://doi.org/10.1134/s199507802006021x

23. Javed R, Rais F, Kaleem M, Jamil B, Ahmad MA, Yu T,et al. Chitosan capping of CuO nanoparticles: facile chemical preparation, biological analysis, and applications in dentistry. Int J Biol Macromol [Internet]. 2020 [Citado 13/05/2024]; 167:1452-1467. Disponible en: https://doi.org/10.1016/j.ijbiomac.2020.11.099

24. Tanweer T, Rana NF, Saleem I, Shafique I, Alshahrani SM, Almukhlifi HA, et al. Dental composites with magnesium doped zinc oxide nanoparticles prevent secondary caries in the alloxan-induced diabetic model. Int J Mol Sci [Internet]. 2022 [Citado 13/05/2024];23(24):15926. Disponible en: https://doi.org/10.3390/ijms232415926

25. Shoorgashti R, Havakhah S, Nowrooz S, Ghadamgahi B, Mehrara R, Oroojalian F. Evaluation of the antibacterial and cytotoxic activities of Ag/ZnO nanoparticles loaded polycaprolactone/chitosan composites for dental applications. Nanomedicina J [Internet]. 2023 [Citado 13/05/2024];10(1):68-76. Disponible en: https://nmj.mums.ac.ir/article_21614.html

26. Alkhazaleh A, Elfagih S, Chakka LR, Armstrong SR, Comnick CL, Qian F,et al. Development of proanthocyanidin-loaded mesoporous silica nanoparticles for improving dental adhesion. Mol Pharm [Internet]. 2022 [Citado 13/05/2024]; ;19(12):4675-84. Disponible en: https://doi.org/10.1021/acs.molpharmaceut.2c00728

27. Larissa P, Gambrill B, de Carvalho RD, Picolo MZ, Cavalli V, Boaro LC,et al. Development, characterization and antimicrobial activity of multilayer silica nanoparticles with chlorhexidine incorporated into dental composites. Dent Mater [Internet]. 2023 [Citado 13/05/2024]; 39(5):469-77. Disponible en: https://doi.org/10.1016/j.dental.2023.03.005

28. Esteban Florez FL, Trofimov AA, Ievlev A, Qian S, Rondinone AJ, Khajotia SS. Advanced characterization of surface-modified nanoparticles and nanofilled antibacterial dental adhesive resins. Sci Rep [Internet]. 2020 [Citado 13/05/2024];10(1). Disponible en: https://doi.org/10.1038/s41598-020-66819-8

29. Baghi S, Solhmirzaei R, Bagherian F, Mortezagholi B, Sarkisians E, Ghadimi S. An assay on the antibacterial performance of Co doped ZnO nanoparticles in dental microbes. Nanomed Researcj J [Internet]. 2023 [Citado 13/05/2024];8(2):210-7. Disponible en: https://www.nanomedicine-rj.com/article_705363.html

30. Ning Z, Chen K, Zheng J, Yang D, Zhou S, Zhou Z. Biomimetic Fe‐hydroxyapatite nanoparticle‐reinforced bisphenol A‐glycol methacrylate/triethyleneglycol‐dimethacrylate resins for dental restorative application. J Appl Polym Sci [Internet]. 2021 [Citado 13/05/2024];139(15):51956. Disponible en: https://doi.org/10.1002/app.51956

31. Jardim RN, Rocha AA, Rossi AM, de Almeida Neves A, Portela MB, Lopes RT,et al. Fabrication and characterization of remineralizing dental composites containing hydroxyapatite nanoparticles. J Mech Behav Biomed Mater [Internet]. 2020 [Citado 13/05/2024];109:103817. Disponible en: https://doi.org/10.1016/j.jmbbm.2020.103817

32. Hassan ZJ, Hamid MK, Ahmed ME. Synthesized zinc oxide nanoparticles by the precipitation method on streptococcus spp from dental carries and cytotoxicity assay. Int J Drug Deliv Technol [Internet]. 2022 [Citado 13/05/2024];12(03):1327-30. Disponible en: https://doi.org/10.25258/ijddt.12.3.65

33. Abd Ali MA, Shareef AA. Antibacterial activity of silver nanoparticles derived from extracellular extract of enterococcus aerogenes against dental disease bacteria isolated. Regen Eng Transl Med [Internet]. 2023 [Citado 13/05/2024];10(9). Disponible en: https://doi.org/10.1007/s40883-023-00304-2

34. Rodrigues MC, Rolim WR, Viana MM, Souza TR, Gonçalves F, Tanaka CJ, et al. Biogenic synthesis and antimicrobial activity of silica-coated silver nanoparticles for esthetic dental applications. J Dent [Internet]. 2020 [Citado 13/05/2024];96:103327. Disponible en: https://doi.org/10.1016/j.jdent.2020.103327

35. Al-Ansari MM, Al-Dahmash ND, Ranjitsingh AJ. Synthesis of silver nanoparticles using gum Arabic: Evaluation of its inhibitory action on Streptococcus mutans causing dental caries and endocarditis. J Infect Public Health [Internet]. 2021 [Citado 13/05/2024];14(3):324-30. Disponible en: https://doi.org/10.1016/j.jiph.2020.12.016

36. Vega-Jiménez AL, González-Alva P, Rodríguez-Hernández AP, Vázquez-Olmos AR, Paz-Díaz B. Oxide nanoparticles based in magnesium as a potential dental tool to inhibit bacterial activity and promote osteoblast viability. Dent Mater J [Internet]. 2024 [Citado 13/05/2024];43(1):11-19. Disponible en: https://doi.org/10.4012/dmj.2023-041

37. Chuang YC, Chang CC, Yang F, Simon M, Rafailovich M. TiO2 nanoparticles synergize with substrate mechanics to improve dental pulp stem cells proliferation and differentiation. Mater Sci Eng [Internet]. Enero de 2021 [Citado 13/05/2024];118:111366. Disponible en: https://doi.org/10.1016/j.msec.2020.111366

38. Zhang M, Liu X, Xie Y, Zhang Q, Zhang W, Jiang X. Biological safe gold nanoparticle-modified dental aligner prevents the porphyromonas gingivalis biofilm formation. ACS Omega [Internet]. 2020 [Citado 13/05/2024];5(30):18685-92. Disponible en: https://doi.org/10.1021/acsomega.0c01532

39. Hossain N, Chowdhury DM, Hossain A, Ahmed MS, Rana MM, Sultana S. Synthesis and characterization of Alocasia indica infused silver nanoparticles for dental implant applications. Chem Phys Impact [Internet]. 2023 [Citado 13/05/2024];6:100239. Disponible en: https://doi.org/10.1016/j.chphi.2023.100239

40. Mansoor A, Khan MT, Mehmood M, Khurshid Z, Ali MI, Jamal A. Synthesis and characterization of titanium oxide nanoparticles with a novel biogenic process for dental application. Nanomaterials [Internet]. 2022 [Citado 13/05/2024];12(7):1078. Disponible en: https://doi.org/10.3390/nano12071078

41. Naguib G, Maghrabi AA, Mira AI, Mously HA, Hajjaj M, Hamed MT. Influence of inorganic nanoparticles on dental materials’ mechanical properties. A narrative review. BMC Oral Health [Internet]. 2023 [Citado 13/05/2024];23(1). Disponible en: https://doi.org/10.1186/s12903-023-03652-1

42. Saygi KO, Bayram HM, Bayram E. Green synthesis of silver nanoparticles using artichoke flower petals and application in endodontic dentistry. Biomass Convers Biorefinery [Internet]. 2022 [Citado 13/05/2024];14(4):1-9. Disponible en: https://doi.org/10.1007/s13399-022-02857-8

43. Klein W, Ismail E, Maboza E, Hussein AA, Adam RZ. Green-Synthesized silver nanoparticles: antifungal and cytotoxic potential for further dental applications. J Funct Biomater [Internet]. 2023 [Citado 13/05/2024];14(7):379. Disponible en: https://doi.org/10.3390/jfb14070379

44. Thyagarajan R, Narendrakumar G, Rameshkumar V, Varshiney M. Green synthesis of Zirconia nanoparticles based on ginger root extract: optimization of reaction conditions, application in dentistry. Res J Pharm Technol [Internet]. 2022 [Citado 21/05/2024]:5314-20. Disponible en: https://doi.org/10.52711/0974-360x.2022.00895

45. Bukovinszky K, Szalóki M, Csarnovics I, Bonyár A, Petrik P, Kalas B, et al. Optimization of plasmonic gold nanoparticle concentration in green LED light active dental photopolymer. Polymers [Internet]. 2021 [Citado 13/05/2024];13(2):275. Disponible en: https://doi.org/10.3390/polym13020275

46. Jiménez-Ramírez AJ, Martínez-Martínez RE, Ayala-Herrera JL, Zaragoza-Contreras EA, Domínguez-Pérez RA, Reyes-López SY, et al. Antimicrobial activity of silver nanoparticles against clinical biofilms from patients with and without dental caries. J Nanomater [Internet]. 2021 [Citado 13/05/2024];2021:1-13. Disponible en: https://doi.org/10.1155/2021/5587455

47. Al-Ansari MM, Al-Dahmash ND, Ranjitsingh AJ. Synthesis of silver nanoparticles using gum Arabic: Evaluation of its inhibitory action on Streptococcus mutans causing dental caries and endocarditis. J Infect Public Health [Internet]. 2021 [Citado 13/05/2024];14(3):324-30. Disponible en: https://doi.org/10.1016/j.jiph.2020.12.016

48. Beketova A, Tzanakakis EG, Vouvoudi E, Anastasiadis K, Rigos AE, Pandoleon P, et al. Zirconia nanoparticles as reinforcing agents for contemporary dental luting cements: physicochemical properties and shear bond strength to monolithic zirconia. Int J Mol Sci [Internet]. 2023 [Citado 13/05/2024];24(3):2067. Disponible en: https://doi.org/10.3390/ijms24032067

Published

2024-06-24

How to Cite

1.
Guamán Hernández VA, Alban C, Crespo V, Espinoza C. Nanoparticles in dentistry: a systematic review. Rev haban cienc méd [Internet]. 2024 Jun. 24 [cited 2025 Jun. 23];23:e5728. Available from: https://revhabanera.sld.cu/index.php/rhab/article/view/5728

Issue

Section

Technological Sciences